Global brands must prioritize consistency, cultural relevance, and accessibility in their web design to effectively engage diverse audiences. Ensuring a cohesive brand identity across all regions is essential, which involves maintaining uniform color schemes, typography, and layouts while allowing for localized content and language adaptation. The design must also accommodate various cultural preferences, such as imagery, tone, and navigation styles that resonate with different markets. Additionally, accessibility standards must be met to ensure usability for all, and the website should be mobile-optimized for global reach, providing a seamless experience across devices and regions.